Magaldrate + Simethicone
Indications
Magaldrate + Simethicone is used for:
Heartburn, Hyperacidity, Indigestion, Dyspepsia, Gastritis, Peptic ulcers, GERD
Adult Dose
Oral
Adult:
Suspension: 2-4 teaspoonful orally 3-4 times daily after 20-60 minutes of meals and at bedtime.
Child Dose
Children 12 years and older:
Suspension: 2-4 teaspoonful orally 3-4 times daily after 20-60 minutes of meals and at bedtime.
Renal Dose
Administration
Take between meals & at bedtime.
Contra Indications
Magaldrate is contraindicated in patients with known hypersensitivity to magnesium and aluminium. It is also contraindicated in patients with impaired renal functions.
Precautions
Care should be taken in decreased kidney function, hypophosphataemia and weak people.
Pregnancy-Lactation
Interactions
Magaldrate may negatively influence drugs like tetracyclines, benzodiazepines, and indomethacin. High doses or prolonged usage may lead to an increment of defecation and a reduction in feces consistence. In some cases it can alter the functionality of the gastrointestinal tract, occasionally provoking constipation or diarrhea.
Adverse Effects
Side effects of Magaldrate + Simethicone :
Chalky taste, Constipation, Fecal impaction, Stomach cramps, Nausea, Vomiting. Loose stool.
Mechanism of Action
Magaldrate is a hydroxymagnesium aluminate complex that is rapidly converted in gastric acid to magnesium and aluminium hydroxide, which is poorly absorbed and provides a sustained antacid effect with balanced efects on intestinal motility; increases lower esophageal sphincter tone and inhibits smooth muscle contraction and gastric emptying.
Simethicone allows gas bubbles in the stomach and intestines to come together more easily, which allows for easier passage of gas.