Magnesium Oxide

Indications

Magnesium Oxide is used for: Magnesium Supplementation, Antacid

Adult Dose

Magnesium Supplementation Tablet: 1-2 tablets PO once a Day Antacid Tablet: 1 tablet PO once a Day or q12hr; not to exceed 2 tablets/day

Child Dose

Renal Dose

CrCl <30 mL/min: Caution; monitor for hypermagnesemia

Administration

Take with food

Contra Indications

Hypersensitivity, Renal failure.

Precautions

Caution with renal impairment Caution with myasthenia gravis or other neuromuscular diseases

Pregnancy-Lactation

Pregnancy Category: A; 350-400 mg/day elemental Mg recommended during pregnancy Lactation: Distributed in breast milk; 310-360 mg/day elemental Mg recommended during lactation

Interactions

May decrease absorption of tetracyclines and bisphosphonates; separate administration of these and other drugs by around 2 hr.

Adverse Effects

Side effects of Magnesium Oxide : Frequency Not Defined Diarrhea with excessive dose Gastrointestinal irritation Vomiting and upset stomach Hypermagnesaemia Paralytic ileus

Mechanism of Action

Mineral; cofactor in many enzymatic reactions and essential for various metabolic functions (eg, phosphate transfer, muscle contraction, nerve conduction)