Mebhydrolin
Indications
Mebhydrolin is used for:
Allergic conditions
Adult Dose
Oral
Allergic conditions
Adult: 100-300 mg/day.
Child Dose
Oral
Allergic conditions
Child: <2 yr: 50-100 mg/day;
2-5 yr: 50-150 mg/day;
5-10 yr: 100-200 mg/day;
>10 yr: 100-300 mg/day.
Renal Dose
Administration
Should be taken with food. Take during or shortly after meals.
Contra Indications
Premature infants and neonates. Acute asthmatic attack.
Precautions
Closed-angle glaucoma; urinary retention, prostatic hyperplasia or pyloroduodenal obstruction; epilepsy. Elderly. Pregnancy. May impair ability to drive or operate machinery.
Pregnancy-Lactation
Interactions
Enhanced sedation with alcohol or other CNS depressants. Additive antimuscarinic effects with MAOIs, atropine, TCAs. May mask warning symptoms caused by ototoxic agents e.g. aminoglycoside antibiotics.
Adverse Effects
Side effects of Mebhydrolin :
CNS depression; paradoxical stimulation (high doses, children or elderly); headache, psychomotor impairment; dry mouth, thickened respiratory tract secretions, blurred vision; urinary difficulty or retention, constipation, increased gastric reflux; nausea, vomiting, diarrhoea, epigastric pain. Rarely, blood disorders. Convulsions, sweating, myalgia, paraesthesias, extrapyramidal effects, tremor, sleep disturbances, depression, confusion, tinnitus, hypotension, hair loss.
Potentially Fatal: Anaphylaxis.
Mechanism of Action
Mebhydrolin is an ethylenediamine derivative antihistamine with antimuscarinic and sedative properties.