Meclizine Hydrochloride + Pyridoxine Hydrochloride

Indications

Meclizine Hydrochloride + Pyridoxine Hydrochloride is used for: Nausea, vomiting, dizziness, motion sickness, radiation sickness and vertigo associated with diseases of vestibular motion sickness, radiation sickness and vertigo associated with diseases of vestibular system, morning sickness during pregnancy, drug induced nausea, vomiting induced by oral contraceptives or Estrogen preparations.

Adult Dose

Oral Motion sickness Adult: 25-50 mg Meclizine 1 hr before travelling and repeat 24 hrly if needed. Vertigo and vestibular disorders Adult: 25-100 mg Meclizine daily in divided doses. Discontinue if there is no response after 1-2 wk of treatment. Radiation sickness: 50 mg Meclizine administered 2-12 hours prior to radiation treatment. Pyridoxine (vitamin B6) has been shown to be safe and effective in dosages of 50 to 200 mg per day.

Child Dose

Oral <12 years: Safety and efficacy not established

Renal Dose

Administration

May be taken with or without food.

Contra Indications

Meclizine Hydrochloride and Pyridoxine Hydrochloride is contraindicated in patients who are hypersensitive to these ingredients.

Precautions

Prostate hypertrophy, obstruction of bladder neck, narrow angle glaucoma, pyloric stenosis. May impair ability to drive or operate machinery. Pregnancy. Lactation: Not known if excreted in milk; use caution

Pregnancy-Lactation

Interactions

Additive effects with CNS depressants, neuroleptics, anticholinergics, alcohol.

Adverse Effects

Side effects of Meclizine Hydrochloride + Pyridoxine Hydrochloride : Drowsiness, thickening of bronchial secretions, dry mouth, fatigue, blurred vision.

Mechanism of Action

Meclozine blocks vasopressor response to histamine and has a slight blocking action against acetylcholine. It decreases excitability of the middle ear labyrinth and blocks conduction in the middle ear vestibular-cerebellar pathways. Pyridoxine is a water-soluble vitamin which functions in the metabolism of carbohydrates, proteins and fats. It is essential in Hb formation and GABA synthesis within the CNS. It also aids in the release of glycogen stored in the liver and muscles.