Meclozine HCl, Pyridoxine HCl
Indications
Meclozine HCl, Pyridoxine HCl is used for:
MECLIZINE
For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness
PYRIDOXINE
For the treatment of vitamin b6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy
For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness
PYRIDOXINE
For the treatment of vitamin b6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Meclozine HCl, Pyridoxine HCl :
Mechanism of Action
MECLIZINE
Along with its actions as an antagonist at h1-receptors, meclizine also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine depresses labyrinth excitability and vestibular stimulation and may affect the medullary chemoreceptor trigger zone
PYRIDOXINE
Vitamin b6 is the collective term for a group of three related compounds, pyridoxine (pn), pyridoxal (pl) and pyridoxamine (pm), and their phosphorylated derivatives, pyridoxine 5'-phosphate (pnp), pyridoxal 5'-phosphate (plp) and pyridoxamine 5'-phosphate (pmp). Although all six of these compounds should technically be referred to as vitamin b6, the term vitamin b6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin b6, principally in its biologically active coenzyme form pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (gaba)
Along with its actions as an antagonist at h1-receptors, meclizine also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine depresses labyrinth excitability and vestibular stimulation and may affect the medullary chemoreceptor trigger zone
PYRIDOXINE
Vitamin b6 is the collective term for a group of three related compounds, pyridoxine (pn), pyridoxal (pl) and pyridoxamine (pm), and their phosphorylated derivatives, pyridoxine 5'-phosphate (pnp), pyridoxal 5'-phosphate (plp) and pyridoxamine 5'-phosphate (pmp). Although all six of these compounds should technically be referred to as vitamin b6, the term vitamin b6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin b6, principally in its biologically active coenzyme form pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (gaba)