Mepyramine Maleate 2% Topical
Indications
Mepyramine Maleate 2% Topical is used for:
Pruritic skin disorders
Adult Dose
Topical/Cutaneous
Hypersensitivity reactions, Pruritic skin disorders
Adult: Apply 2% cream on affected areas.
Child Dose
Renal Dose
Administration
Contra Indications
Severe liver disease; premature infants or full-term neonates; eczema (topical).
Precautions
Pregnancy; lactation; severe CV disorders; asthma; drowsiness; angle-closure glaucoma, urinary retention, prostatic hyperplasia, pyloroduodenal obstruction; renal and hepatic impairment; elderly; epilepsy. May affect ability to drive and operate machinery. Broken skin (topical).
Pregnancy-Lactation
Interactions
increased effects with CNS depressants (e.g. alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and neuroleptics). Additive effects with other antimuscarinics (e.g. TCAs, atropine).
Adverse Effects
Side effects of Mepyramine Maleate 2% Topical :
Sedation; antimuscarinic effects, CNS depression and disturbances; occasionally, paradoxical CNS stimulation; psychomotor impairment; headache; palpitations and arrhythmias; convulsions, sweating, myalgia, paraesthesias, extrapyramidal symptoms, tremor, sleep and GI disturbances, hypersensitivity reactions and blood dyscrasias; hypotension; hair loss; tinnitus.
Mechanism of Action
Mepyramine is an ethylenediamine derived antihistamine with antimuscarinic and sedating properties.