Mesterolone
Indications
Mesterolone is used for:
Orally active androgen indicated in hypogonadism, infertility, potency disturbance, reduced efficiency in middle and advanced age
Adult Dose
Oral
Androgen deficiency and male infertility associated with hypogonadism, 25 mg 3–4 times daily for several months.
Maintenance: 50–75 mg daily in divided doses
Potency disturbances and diminishing efficiency, initially 25 mg 3 times daily; may be reduced according to patient’s need. Maintenance: 25 mg 1–2 times daily for several months
Child Dose
CHILD: Not recommended
Renal Dose
Administration
For Oral use
Contra Indications
Breast cancer in men, prostate cancer, hypercalcaemia, pregnancy, breastfeeding, nephrotic syndrome, history of primary liver tumours
Precautions
Cardiac, renal or hepatic impairment (Appendix 5), elderly, ischaemic heart disease, hypertension, epilepsy, migraine, diabetes mellitus, skeletal metastases (risk of hypercalcaemia); regular examination of prostate and breast during treatment; prepubertal boys
Pregnancy-Lactation
Recommendations on the use of Mesterolone in Pregnancy & Lactation:
Similar to other androgens, Mesterolone is contraindicated during pregnancy and lactation (Schaefer et al., 2015).
References:
1. Schaefer, C., Peters, P., & Miller, R. K. (2015). Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment (Third Edition). Academic Press
Interactions
Adverse Effects
Side effects of Mesterolone :
Rarely benign and malignant liver tumours. Frequent or persistent erections may occur (reduce dose or discontinue)