Mesterolone

Indications

Mesterolone is used for: Orally active androgen indicated in hypogonadism, infertility, potency disturbance, reduced efficiency in middle and advanced age

Adult Dose

Oral Androgen deficiency and male infertility associated with hypogonadism, 25 mg 3–4 times daily for several months. Maintenance: 50–75 mg daily in divided doses Potency disturbances and diminishing efficiency, initially 25 mg 3 times daily; may be reduced according to patient’s need. Maintenance: 25 mg 1–2 times daily for several months

Child Dose

CHILD: Not recommended

Renal Dose

Administration

For Oral use

Contra Indications

Breast cancer in men, prostate cancer, hypercalcaemia, pregnancy, breastfeeding, nephrotic syndrome, history of primary liver tumours

Precautions

Cardiac, renal or hepatic impairment (Appendix 5), elderly, ischaemic heart disease, hypertension, epilepsy, migraine, diabetes mellitus, skeletal metastases (risk of hypercalcaemia); regular examination of prostate and breast during treatment; prepubertal boys

Pregnancy-Lactation

Recommendations on the use of Mesterolone in Pregnancy & Lactation: Similar to other androgens, Mesterolone is contraindicated during pregnancy and lactation (Schaefer et al., 2015). References: 1. Schaefer, C., Peters, P., & Miller, R. K. (2015). Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment (Third Edition). Academic Press

Interactions

Adverse Effects

Side effects of Mesterolone : Rarely benign and malignant liver tumours. Frequent or persistent erections may occur (reduce dose or discontinue)

Mechanism of Action