Methadone HCl
Indications
Methadone HCl is used for:
For the treatment of dry cough, drug withdrawal syndrome, opioid type drug dependence, and pain
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Methadone HCl :
Mechanism of Action
Methadone is a mu-agonist; a synthetic opioid analgesic with multiple actions qualitatively similar to those of morphine, the most prominent of which involves the central nervous system and organs composed of smooth muscle. The principal therapeutic uses for methadone are for analgesia and for detoxification or maintenance in opioid addiction. The methadone abstinence syndrome, although qualitatively similar to that of morphine, differs in that the onset is slower, the course is more prolonged, and the symptoms are less severe. Some data also indicate that methadone acts as an antagonist at the n-methyl-d-aspartate (nmda) receptor. The contribution of nmda receptor antagonism to methadone's efficacy is unknown. Other nmda receptor antagonists have been shown to produce neurotoxic effects in animals