Methenamine + Sodium salicylate Benzoic acid
Indications
Methenamine + Sodium salicylate Benzoic acid is used for:
Urinary Tract Infection Prophylaxis
Adult Dose
Urinary Tract Infection Prophylaxis
2 tablets PO q12hr
Child Dose
Renal Dose
Administration
Contra Indications
Contraindications
Methenamine
Hypersensitivity to methenamine or tartrazine (FD&C Yellow No. 5)
Renal or severe hepatic insufficiency
Concurrent sulfonamides or acetazolamide may form insoluble precipitate in urine
Sodium Salicylate
Hypersensitivity to aspirin or NSAIDs
Bleeding gastrointestinal ulcers
Asthma, Nasal polyps associated with asthma
Hemolytic anemia from PK & G6PD deficiency
Hemophilia
Hemorrhagic diathesis
Hemorrhoids, Lactating women, Sarcoidosis, Thrombocytopenia, Ulcerative colitis
Precautions
Methenamine
Large doses may cause bladder irritation, urinary frequency, albuminuria, and hematuria
Maintain acidic pH of urine, especially when treating urea-splitting organisms (eg, Proteus, Pseudomonas)
Monitor LFTs, especially with history of liver impairment
Safe use not established during pregnancy, especially 1st and 2nd trimester
May precipitate uric acid stones in patients with gout
Sodium Salicylate
Anemia
GI malabsorption
History of peptic ulcers
Gout
Hepatic disease
Hypochlorhydria, Hypoprothrombinemia, Renal impairment, Renal calculi, Thyrotoxicosis, Vitamin K deficiency
Pregnancy-Lactation
Pregnancy Category: C
Lactation: methenamine is excreted in human milk; caution advised, risk to infant cannot be ruled out
Interactions
Adverse Effects
Side effects of Methenamine + Sodium salicylate Benzoic acid :
1-10%
Methenamine
Dysuria
Gastric upset
Nausea
Rash
Frequency Not Defined
Sodium salicylate
Angioedema
Bronchospasm
CNS alteration
Dermatologic problems
GI pain/ulceration/bleeding
Hepatotoxicity
Hearing loss
Mechanism of Action
Methenamine: Hydrolyzed in acidic urine to ammonia and formaldehyde, which are bactericidal agents; does not convert to formaldehyde in serum.
Sodium salicylate: Analgesic
Benzoic acid: Elicits weak antifungal and antibacterial properties; also helps acidify urine