Methyl Ergometrine Maleate
Indications
Methyl Ergometrine Maleate is used for:
Migraine, Miscarriage, Uterine hemorrhage, Spontaneous or elective abortion, Uterine atony, Second stage of labor
Adult Dose
Oral:
Prophylaxis of postpartum haemorrhage
Adult: 200 mcg 3-4 times daily in the puerperium for 2-7 days.
Intramuscular
Treatment and prophylaxis of postpartum and postabortal haemorrhage
Adult: 200 mcg. May repeat every 2-4 hr. Max: 5 doses.
Intravenous
Treatment and prophylaxis of postpartum and postabortal haemorrhage
Adult: As an emergency measure: 200 mcg by slow inj over at least 1 minute, may repeat every 2-4 hr, up to a max of 5 doses.
Child Dose
Renal Dose
Administration
Contra Indications
Hypertension, eclamptic or previously hypertensive patients, heart disease, venoatrial shunts, mitral valve stenosis, obliterative vascular disease. Do not use in cases of threatened spontaneous abortion. Pregnancy.
Precautions
Captivation of the placenta may occur if given during the 2nd or 3rd stage of labour prior to delivery of the placenta; use in this situation should only be done by a qualified personnel. Avoid prolonged use. Caution in patients with sepsis, hepatic or renal impairment. Lactation.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Methyl Ergometrine Maleate :
Headache, dizziness, hallucinations; tinnitus; nausea, vomiting, foul taste, diarrhoea; hypertension, temporary chest pain, palpitations, bradycardia; nasal congestion, dyspnoea; diaphoresis; thrombophlebitis; haematuria; water intoxication; leg cramps; allergic reactions.
Potentially Fatal: Shock.
Mechanism of Action
Ergometrine causes contraction of the uterine muscle. At low doses, there is an increase in frequency and amplitude of contractions while at higher doses, the basal tone of the uterus is increased. Ergometrine also causes vasoconstriction of peripheral and cerebral vessels.