Metronidazole + Neomycin Sulphate + Nystatin + Polmyxin B Vag prep
Indications
Metronidazole + Neomycin Sulphate + Nystatin + Polmyxin B Vag prep is used for:
Vaginal trichomoniasis, Vaginal leucorrhoea, Bacterial or fungal vaginal infection
Adult Dose
Per Vagina: One suppository to be inserted into vagina at bedtime for 12 days.
As Vag Capsule: 100 mg every night for 7-14 days.
Child Dose
Renal Dose
Administration
Contra Indications
Contraindicated in patients who are hypersensitive to any component of this product.
Precautions
Caution should be taken in case of renal impaired patients.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Metronidazole + Neomycin Sulphate + Nystatin + Polmyxin B Vag prep :
Skin rash and urticaria, local irritation and sensitisation may occur rarely.
Mechanism of Action
Metronidazole is converted to reduction products that interact w/ DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms. It is active against most anaerobic protozoa, some gm+ve, gm-ve and facultative anaerobes.
Nystatin, a polyene antifungal, binds to ergosterol in the fungal cell membrane. This binding affects the cell wall permeability allowing leakage of cellular contents.
Polymyxin B disrupts the bacterial cytoplasmic membrane of mostly gm-ve organisms allowing leakage of intracellular constituents by binding to membrane phospholipids.
Neomycin is an aminoglycoside antibiotic. It binds to 30S ribosomal subunits of bacterial ribosome thus inhibiting protein synthesis and generating errors in genetic code transcription causing cell death. It acts against many gram-negative aerobes and some gram-positive aerobes. It lacks activity against fungi, viruses and most anaerobic bacteria.