Miconazole vaginal prep

Indications

Miconazole vaginal prep is used for: Vulvovaginal candidiasis

Adult Dose

Vaginal Vulvovaginal candidiasis Adult: As 2% cream (approx 5 g): Apply intravaginally at bedtime once daily for 10-14 days or bid for 7 days. Continue treatment even after pruritus and leukorrhoea have disappeared or menstruation begins. As pessary/suppository: 100 mg once daily preferably at bedtime for 7 or 14 days, 100 mg bid for 7 days, 200 mg or 400 mg daily for 3 days, or 1,200 mg as a single dose. As vaginal cap: 1,200 mg inserted intravaginally at bedtime as a single dose.

Child Dose

Vulvovaginal Candidiasis < 12 years Safety and efficacy not established > 12 years Vaginal 2% cream: 1 applicatorful qHS x 7 days Vaginal 4% cream: 1 applicatorful qHS x 3 days 100 mg vaginal suppository: Insert 1 suppository qHS x 7 days 200 mg vaginal suppository: Insert 1 suppository qHS x 3 days 1,200 mg vaginal suppository: Insert 1 suppository once

Renal Dose

Administration

Contra Indications

Pregnancy: 1st trimester Known hypersensitivity to drug

Precautions

Hypersensitivity to other azoles Avoid contact with eyes Patient Counselling Vaginal preparations may decrease the effectiveness of latex contraceptive agents (e.g. condoms and diaphragms).

Pregnancy-Lactation

Pregnancy Category: C Lactation: unknown

Interactions

Adverse Effects

Side effects of Miconazole vaginal prep : Frequency Not Defined Allergic contact dermatitis Burning Irritation Itching Abdominal cramps

Mechanism of Action

Miconazole, an imidazole derivative antifungal agent, inhibits the ergosterol biosynthesis in fungi and changes the composition of other lipid components in the membrane, thereby resulting in fungal cell necrosis.