Minocycline topical

Indications

Minocycline topical is used for: Acne Vulgaris

Adult Dose

Acne Vulgaris Indicated for treatment of inflammatory lesions of non-nodular moderate-to-severe acne vulgaris Apply to acne-affected areas qHS; repeat application until all affected areas are treated Apply additional amounts of topical foam if acne is present on other parts of the patient’s body (neck, shoulders, arms, back, or chest)

Child Dose

Renal Dose

Administration

For topical use only; not for oral, ophthalmic, or intravaginal use Shake can well and measure small amount of topical foam (eg, cherry-sized amount) from can onto fingertips and rub into acne-affected areas Repeat this process until all acne-affected areas are treated Apply at approximately the same time each day at least 1 hr before bedtime Instruct patient not to bathe, shower, or swim for at least 1 hr after application

Contra Indications

Hypersensitivity to any tetracycline or other ingredient

Precautions

Flammable; caution patient to avoid fire, flame, and smoking during and immediately following application; do not puncture or incinerate containers

Pregnancy-Lactation

Pregnancy Available data with topical minocycline use in pregnant women are insufficient to evaluate for a drug-associated risk of major birth defects, miscarriage, or other adverse maternal or fetal outcomes Systemic absorption in humans is low following once-daily topical administration for 21 days Because of low systemic exposure, it is not expected that maternal use of topical minocycline will result in significant fetal exposure Tetracycline-class drugs may cause permanent discoloration of teeth and reversible inhibition of bone growth when administered orally during pregnancy Lactation Tetracycline-class drugs, including minocycline, are present in breast milk following oral administration Unknown whether minocycline is present in human milk after topical administration to breastfeeding women There are no data on the effects of minocycline on milk production Owing to the potential for serious adverse reactions, advise patients that breastfeeding is not recommended during treatment

Interactions

Tetracyclines have been shown to depress plasma prothrombin activity; patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin False elevations of urinary catecholamine levels may occur owing to interference with the fluorescence test

Adverse Effects

Side effects of Minocycline topical : >10% Erythema, mild (14.2%) Hyperpigmentation, mild (12.4%) 1-10% Dryness, mild (6.8%) Itching, mild (5.1%) Skin peeling, mild (3.2%) Headache (3%) Hyperpigmentation, moderate (2.8%) Erythema, moderate (1.5%) <1% Dryness, moderate Skin peeling, moderate Itching moderate

Mechanism of Action

Precise mechanism of action by which topical minocycline exerts its affects for acne is unknown