Mometasone Furoate 0.1% Topical

Indications

Mometasone Furoate 0.1% Topical is used for: Psoriasis, Corticosteroid- responsive dermatoses

Adult Dose

Topical/Cutaneous Corticosteroid-responsive dermatoses Adult: As 0.1% cream/oint: Apply a thin film to affected area once daily.

Child Dose

Topical/Cutaneous Corticosteroid-responsive dermatoses Child: >2 yr As 0.1% cream/oint: Apply a thin film to affected area once daily for not more than 3 wk.

Renal Dose

Administration

Contra Indications

The drug is contraindicated in individuals with a history of sensitivity reactions to Mometasone or any of the components of the preparation.

Precautions

If irritation develops with the use of Mometasone Furoate cream, treatment should be discontinued. Lactation: use caution

Pregnancy-Lactation

Pregnancy Category: C Lactation: use caution

Interactions

Strong CYP3A4 inhibitors (e.g. ketoconazole) may increase systemic exposure of mometasone.

Adverse Effects

Side effects of Mometasone Furoate 0.1% Topical : Burning, Pruritus, Itching, Rosacea and skin atrophy may occur.

Mechanism of Action

Mometasone depresses the formation, release and activity of endogenous inflammatory chemical mediators (e.g. kinins, histamine, liposomal enzymes and prostaglandin). It inhibits the margination and subsequent cell migration to the injury site, reverses vascular dilatation and permeability, resulting in decreased access of cells to the area of injury.