Mometasone Furoate 0.1% Topical
Indications
Mometasone Furoate 0.1% Topical is used for:
Psoriasis, Corticosteroid- responsive dermatoses
Adult Dose
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: As 0.1% cream/oint: Apply a thin film to affected area once daily.
Child Dose
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Child: >2 yr As 0.1% cream/oint: Apply a thin film to affected area once daily for not more than 3 wk.
Renal Dose
Administration
Contra Indications
The drug is contraindicated in individuals with a history of sensitivity reactions to Mometasone or any of the components of the preparation.
Precautions
If irritation develops with the use of Mometasone Furoate cream, treatment should be discontinued.
Lactation: use caution
Pregnancy-Lactation
Pregnancy Category: C
Lactation: use caution
Interactions
Strong CYP3A4 inhibitors (e.g. ketoconazole) may increase systemic exposure of mometasone.
Adverse Effects
Side effects of Mometasone Furoate 0.1% Topical :
Burning, Pruritus, Itching, Rosacea and skin atrophy may occur.
Mechanism of Action
Mometasone depresses the formation, release and activity of endogenous inflammatory chemical mediators (e.g. kinins, histamine, liposomal enzymes and prostaglandin). It inhibits the margination and subsequent cell migration to the injury site, reverses vascular dilatation and permeability, resulting in decreased access of cells to the area of injury.