Mustine HCl
Indications
Mustine HCl is used for:
For the palliative treatment of hodgkin's disease (stages iii and iv), lymphosarcoma, chronic myelocytic or chronic lymphocytic leukemia, polycythemia vera, mycosis fungoides, and bronchogenic carcinoma. Also for the palliative treatment of metastatic carcinoma resulting in effusion
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Mustine HCl :
Mechanism of Action
Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to dna bases, resulting in the dna being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing dna synthesis and rna transcription from the affected dna, 2) dna damage via the formation of cross-links (bonds between atoms in the dna) which prevents dna from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations. Mechlorethamine is cell cycle phase-nonspecific