Nandrolone
Indications
Nandrolone is used for:
Postmenopausal osteoporosis, Metastatic breast cancer, Anaemia of chronic renal failure, Anaemia in chemotherapy patients
Adult Dose
Intramuscular
As anabolic after debilitating illness; Postmenopausal osteoporosis; Metastatic breast cancer
Adult: As decanoate: 25-100 mg once every 3-4 wk.
Anaemia of chronic renal failure
Adult: As decanoate: 50-200 mg wkly.
Anaemia in chemotherapy patients
Adult: 50-150 mg wkly.
Child Dose
Renal Dose
Administration
Contra Indications
Prostatic or breast carcinoma (male); nephrosis, porphyria; infants, pregnancy and lactation.
Precautions
Monitor diabetic patients carefully. Conditions influenced by oedema (e.g. CV disease, migraine, seizure disorder, renal impairment). Hepatic impairment. Elderly. Discontinue if signs of virilisation in women occur. Monitor skeletal maturation in children.
Pregnancy-Lactation
Interactions
May increase effects of oral anticoagulants, insulin, oral antidiabetic agents, adrenal steroid, adrenocorticotropic hormone (ACTH).
Adverse Effects
Side effects of Nandrolone :
Male: Postpubertal: Acne, gynaecomastia, bladder irritability, priapism, insomnia, chills, decreased libido, hepatic dysfunction, nausea, diarrhoea, prostatic hyperplasia. Prepubertal: Acne, virilism, chills, insomnia, hyperpigmentation, diarrhoea, nausea.
Female: Virilism, hypercalcaemia, nausea, diarrhoea, chills, insomnia, iron deficiency anaemia, hepatic dysfunction.
Mechanism of Action
Nandrolone is an anabolic steroid. It promotes tissue-building processes and protein anabolism. It also stimulates erythropoeitin production, causing an increase in haemoglobin and RBC volume.