Naphazoline + Phenylephrine eye prep

Indications

Naphazoline + Phenylephrine eye prep is used for: For temporary relief of burning & irritation caused by dust, smoke, sun glare, swimming, TV, contact lenses, cold & superficial inflammatory or allergic eye conditions.

Adult Dose

Ophthalmic Instill 1-2 drops into affected eye(s) bid or tid.

Child Dose

Child: >12 Ophthalmic Instill 1-2 drops into affected eye(s) bid or tid.

Renal Dose

Administration

Contra Indications

Ophth: Narrow-angle glaucoma, corneal damage, acute iritis and other serious eye disease.

Precautions

Patient w/ CV disease, HTN, DM, hyperthyroidism, local infection or injury. Childn. Pregnancy and lactation. Patient Counselling This drug may cause drowsiness, temporary blurred vision, and transient mydriasis, if affected, do not drive or operate machinery. Remove contact lenses prior to ophth admin and reinsert after 10-15 min.

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Naphazoline + Phenylephrine eye prep : Significant: Rebound vasodilation or congestion (prolonged/frequent use). Nervous: Nervousness, headache, drowsiness, dizziness, weakness. GI: Nausea. CV: Cardiac irregularities, HTN. Resp: Burning, stinging, sneezing, increased discharge (nasal). Endocrine:Hyperglycaemia. Ophthalmologic: Mydriasis, ocular hyperaemia, increased redness, irritation, discomfort, blurred vision, punctuate keratitis, lacrimation, increased intraocular pressure. Dermatologic: Sweating. Ophthalmic solutions may liberate pigment granules from the iris, corneal clouding/damage.

Mechanism of Action

Naphazoline is an alpha adrenergic receptor agonist which causes vasoconstriction by stimulating arterioles of the conjunctiva and nasal mucosa thus reducing swelling, redness and discomfort when applied to mucous membranes. Phenylephrine causes vasoconstriction of the arterioles of the nasal mucosa and conjunctiva; activates the dilator muscle of the pupil to cause contraction; produces vasoconstriction of arterioles in the body and produces systemic arterial vasoconstriction.