Natamycin 5% Eye prep
Indications
Natamycin 5% Eye prep is used for:
Fungal Conjunctivitis, Keratitis, Blepharitis
Adult Dose
Ophthalmic
For fungal keratitis: The preferred initial dosage is 1 drop instilled in the conjuntival sac (s) at 1-2 hours interval. The frequency of application can usually be reduced to 1 drop 6-8 times daily after the first 3-4 days.
Therapy should generally be continued for 14 to 21 days or until there is resolution of active fungal keratitis. In many cases, it may be helpful to reduce the dosage gradually at 4 to 7 days intervals to assure the replicating fungus has been eliminated.
For fungal blepharitis & conjunctivitis:
Less frequent initial dosage, 1 drop 4-6 times daily may be sufficient.
Child Dose
Safety & efficacy not established
Renal Dose
Administration
Contra Indications
Natamycin sterile ophthalmic suspension is contraindicated in individuals with a known hypersensitivity to any of its components.
Precautions
For topical eye use only. Failure of improvement of keratitis following 7-10 days of administration of the drug suggests that the infection may be caused by a microorganism not susceptible to natamycin.
Pregnancy-Lactation
Pregnancy Category: C
Lactation: no problems reported
Interactions
Potentially Fatal: May increase spread of fungal eye infection when used w/ topical corticosteroid.
Adverse Effects
Side effects of Natamycin 5% Eye prep :
Local irritation, conjunctival chemosis, hyperemia, etc.
Mechanism of Action
Natamycin is a polyene antifungal antibiotic which acts by increasing cell membrane permeability in susceptible fungi. It is active against a variety of yeast and filamentous fungi.