Nateglinide

Indications

Nateglinide is used for: Type 2 DM

Adult Dose

Oral Type 2 diabetes mellitus Adult: 60 or 120 mg tid.

Child Dose

Renal Dose

Administration

Take immediately before or up to ½ hr before meals.

Contra Indications

Diabetic ketoacidosis; IDDM. Lactation.

Precautions

Geriatric patients, debilitated and malnourished patients; adrenal or pituitary insufficiency, moderate to severe hepatic impairment; severe renal impairment. Monitor glycaemic levels during periods of stress. Pregnancy. Lactation: unsafe

Pregnancy-Lactation

Pregnancy Category: C Lactation: unsafe

Interactions

Increased levels/effects with enzyme inhibitors (e.g. fluconazole). Increased hypoglycaemic effects with salicylates, MAOIs, nonselective beta-blockers, alcohol, NSAIDs. Decreased levels/effects with enzyme inducers (e.g. rifampicin). Decreased hypoglycaemic effects with thiazide diuretics, corticosteroids, thyroid products and sympathomimetic agents.

Adverse Effects

Side effects of Nateglinide : 1-10% Increased uric acid (10%), Dizziness (4%), Arthropathy (3%), Flu-like syndrome, Weight gain, Hypoglycemia (2%) Frequency Not Defined Diarrhea, Nausea

Mechanism of Action

Nateglinide, a nonsulfonylurea hypoglycaemic agent, acts by stimulating insulin release from pancreatic ?-cells to reduce postprandial hyperglycaemia. This action depends on the amount of existing glucose levels.