Neomycin Sulphate 0.35% + Polymixin B Sulphate 0.127% + Prednisolone 0.5% Eye prep
Indications
Neomycin Sulphate 0.35% + Polymixin B Sulphate 0.127% + Prednisolone 0.5% Eye prep is used for:
Bacterial ocular infection, Steroid-responsive inflammatory ocular conditions, Conjunctivitis, Keratitis,
Adult Dose
Opthalmic
Adult: Instill 1-2 drops on eye every 3 or 4 hours, or more frequently as required.
Acute infections may require administration every 30 minutes, with frequency of administration reduced as the infection is brought under control.
To treat the lids: Instill 1-2 drops in the eye every 3 to 4 hours, close the eye and rub the excess on the lids and lid margins.
Child Dose
Renal Dose
Administration
Contra Indications
Prednisolone Acetate is contraindicated in viral diseases of the cornea, conjunctiva and known hypersensitivity to any of the ingredients of this preparation or other corticosteroids.
Precautions
This combination should be used with caution in patients with known hypersensitivity to the components of this preparation. Prolonged use of corticosteroids may result in damage to the optic nerve and defects in vision. If this product is used for longer period of time, intraocular pressure should be routinely monitored.
Pregnancy-Lactation
Interactions
Synergistic effects with penicillins. Additive toxicity with neurotoxic, ototoxic or nephrotoxic drugs. May decrease absorption of digoxin and methotrexate. May increase effects of oral anticoagulants.
Adverse Effects
Side effects of Neomycin Sulphate 0.35% + Polymixin B Sulphate 0.127% + Prednisolone 0.5% Eye prep :
Elevation of intraocular pressure (IOP) with possible development of glaucoma and infrequent optic nerve damage, posterior subcapsular cataract formation and delayed wound healing.
Fungal and viral infections of the cornea are particularly may develop coincidentally with long-term applications of steroid
Mechanism of Action
Neomycin: Interferes with bacterial protein synthesis by binding to 30S ribosomal subunits.
Prednisolone decreases inflammation by inhibition of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability. It suppresses the immune system by reducing the activity and production of the lymphocytes and eosinophils.
Polymyxin B: Bactericidal; causes leakage of bacterial membrane