Neomycin Sulphate 0.4% + Polymixin B Sulphate + Pramoxine 1% Topical

Indications

Neomycin Sulphate 0.4% + Polymixin B Sulphate + Pramoxine 1% Topical is used for: Burns, Scrapes, Skin and skin structure infections, Cuts

Adult Dose

Topical Adults: Apply on the area 1 to 3 times daily

Child Dose

Topical Children 2 years of age and older: Apply on the area 1 to 3 times daily

Renal Dose

Administration

Clean the affected area. Apply a small amount of this product (an amount equal to the surface area of the tip of a finger) on the area. May be covered with a sterile bandage.

Contra Indications

Hypersensitivity to aminoglycosides and any of its components. Pre-existing nerve deafness. TB, fungal or viral infections. Do not use in external eardrum if tympanic membrane is perforated.

Precautions

Possibility of ototoxicity, nephrotoxicity and exogenous hyperadrenocorticism if used in large quantities or on large areas for prolonged use

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Neomycin Sulphate 0.4% + Polymixin B Sulphate + Pramoxine 1% Topical : Skin sensitisation. Cream: Burning, itching, irritation, hypopigmentaion, skin atrophy, striae.

Mechanism of Action

Neomycin: Interferes with bacterial protein synthesis by binding to 30S ribosomal subunits. Polymyxin B: Bactericidal; causes leakage of bacterial membrane. Pramoxine provides local anesthetic effect.