Neomycin Sulphate Topical
Indications
Neomycin Sulphate Topical is used for:
Corticosteroid-responsive dermatoses with secondary infection, Skin infections
Adult Dose
Topical
Adult
Corticosteroid-responsive dermatoses with secondary infection
Apply cream/ointment to the affected area 2 to 3 times daily for 7 days
Child Dose
Topical
Child: >2 years
Corticosteroid-responsive dermatoses with secondary infection
Apply cream/ointment to the affected area 2 to 3 times daily for 5 days
Renal Dose
Administration
Contra Indications
- Acne vulgaris.
- Perioral dermatitis.
- Perianal and genital pruritus.
- Primary cutaneous viral infections (e.g. herpes simplex, chickenpox).
- Hypersensitivity to any component of the preparation.
Lactation: use with caution
Precautions
Long-term continuous topical therapy should be avoided where possible, particularly in infants and children. Infants and children up to four years should not be treated with topical steroids for longer than 3 weeks without medical review.
Pregnancy-Lactation
Interactions
Synergistic effects with penicillins. Additive toxicity with neurotoxic, ototoxic or nephrotoxic drugs. May decrease absorption of digoxin and methotrexate. May increase effects of oral anticoagulants.
Adverse Effects
Side effects of Neomycin Sulphate Topical :
Burning, itching, irritation, dryness, folliculitis, hypertrychosis, acneiform eruptions, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae and miliaria may be reported.
Mechanism of Action
Neomycin, an aminoglyoside with antimicrobial spectrum similar to gentamicin, binds to the 30S subunits of the bacterial ribosome, inhibiting protein synthesis and thereby disrupting DNA synthesis. It is active against many gram-negative aerobes and against some strains of staphylococci.