Oxiconazole 1% Topical
Indications
Oxiconazole 1% Topical is used for:
Tinea pedis, Tinea cruris, Tinea corporis, Pityriasis versicolor
Adult Dose
Topical/Cutaneous
Tinea cruris; Tinea corporis; Tinea pedis
Adult: Apply 1% cream once or bid.
Duration of treatment: 2 wk for tinea corporis and tinea cruris or 1 mth for tinea pedis.
Pityriasis versicolor
Adult: As 1% cream: Apply to affected areas once daily for 2 wk.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity.
Precautions
Pregnancy and lactation. Avoid contact with eyes. Discontinue if irritation or sensitisation occurs. Cross-sensitisation with other imidazole derivatives may occur.
Lactation: distributed into milk; use with caution in nursing women
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Oxiconazole 1% Topical :
1-10%
Pruritus (1-2%), Burning (1-2%)
<1%
Irritation, Stinging, Erythema, Rash, Folliculitis, Papules, Nodules, Maceration, Fissuring
Mechanism of Action
Oxiconazole, a synthetic azole antifungal, is usually fungistatic but may be fungicidal in high concentrations. It exerts its antifungal activity by interfering w/ ergosterol synthesis and altering cellular membranes. It also has some antibacterial activity against aerobic gm+ve organisms.