Oxyphencyclimine Hydrochloride
Indications
Oxyphencyclimine Hydrochloride is used for:
Peptic ulcer disease, smooth muscle spasms in gastrointestinal disorders
Adult Dose
Oral
Peptic ulcer
Adult: 5-10 mg bid or tid
Child Dose
Renal Dose
Administration
Contra Indications
Closed-angle glaucoma; obstructive uropathy; GI obstruction, paralytic ileus, intestinal atony, ulcerative colitis; toxic megacolon; myasthenia gravis.
Precautions
Elderly; autonomic neuropathy; hepatic or renal disease; hyperthyroidism, CHF, thyrotoxicosis, MI, tachyarrhythmias, hypertension, prostatic hypertrophy; hiatal hernia. May impair ability to drive or operate machinery. Pregnancy and lactation. Down's syndrome.
Pregnancy-Lactation
Interactions
Enhanced effect with concurrent admin of other drugs with antimuscarinic properties and MAOIs. May affect absorption of other drugs. Antagonistic effect with parasympathomimetics.
Adverse Effects
Side effects of Oxyphencyclimine Hydrochloride :
Xerostomia, decreased sweating, urinary hesitancy and retention, blurred vision, cycloplegia, increased ocular tension, loss of taste, headache, nervousness, mental confusion, impotence, suppression of lactation, urticaria, constipation.
Mechanism of Action
Oxyphencyclimine is a tertiary amine antimuscarinic. It blocks all three types of muscarinic receptors and inhibits vagally mediated reflexes by antagonising the action of acetylcholine.