Oxyphenonium Bromide 1% Eye prep
Indications
Oxyphenonium Bromide 1% Eye prep is used for:
Dilatation of pupil
Adult Dose
Ophthalmic
1-2 drops or as required.
Child Dose
Renal Dose
Administration
Contra Indications
Patients with urinary obstruction, paralytic ileus and myasthenia gravis.
Precautions
Caution should be exercised in patients with history of high blood pressure, increased eye pressure, elderly, children, during pregnancy and breastfeeding.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Oxyphenonium Bromide 1% Eye prep :
Eye- Blurred vision and sensitivity to sunlight.
Mechanism of Action
Oxyphenonium is an anticholinergic drug. It exerts its action by inhibiting muscarinic (cholinergic) receptors on smooth muscles, cardiac muscles and prevents the effect of Acetylcholine. Inhibition of Acetylcholine produces relaxation of smooth muscles and prevents the muscle spasm in irritable bowel syndrome.
Oxyphenonium also has a direct relaxant effect on smooth muscle. It also inhibits gastrointestinal propulsive movement and decreases gastric acid secretion and control bronchial, pharyngeal and tracheal secretions. It also possesses nicotinic blocking activity and interferes with ganglionic or neuromuscular transmission. It cross the BBB poorly and does not produce CNS effect.