Oxytetracycline 0.5% + Polymixin B Sulphate E/E prep
Indications
Oxytetracycline 0.5% + Polymixin B Sulphate E/E prep is used for:
Ocular infections, Aural infections
Adult Dose
Adult & Child: As Eye ointment: Apply 2 hourly in acute infection.
Ear ointment: Small amount of ointment in the external auditory meatus 2-4 times daily.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity.
Precautions
Avoid prolonged use. Perforated ear drum.
Pregnancy-Lactation
Interactions
Antacids, iron, aluminum, calcium, magnesium, zinc salts reduce absorption. Concurrent use may cause increased levels of lithium, digoxin, halofantrine and theophylline; decreased concentrations of atovaquone. Increased risk of ergotism with ergot alkaloids. May cause failure of oral contraception.
Potentially Fatal: Interferes with anticoagulant control. Nephrotoxic effects exacerbated by diuretics, methoxyflurane or other nephrotoxic drugs; avoid concurrent use with potentially hepatotoxic drugs. Increased incidence of benign intracranial hypertension with retinoids.
Adverse Effects
Side effects of Oxytetracycline 0.5% + Polymixin B Sulphate E/E prep :
Local irritation. Occular or Oto toxicity.
Mechanism of Action
Oxytetracycline binds reversibly to the 30S and possibly 50S ribosomal subunits, thus inhibiting bacterial protein synthesis and arresting cell growth. It is active against a wide range of gram-positive and gram-negative organisms.
Polymyxin B: Bactericidal; causes leakage of bacterial membrane.