Paracetamol + Phenylephrine + Guaifenesin

Indications

Paracetamol + Phenylephrine + Guaifenesin is used for: Temporary Relief of Sinus Congestion, Headache, Minor Aches & Pains

Adult Dose

Temporary Relief of Sinus Congestion, Headache, Minor Aches & Pains 2 tabs PO q4hr; not to exceed 12 tabs/24hr; not to exceed 1g/hr or 4g/day of Paracetamol 30 mL [(325mg/5mg/200mg)/15mL] PO q4hr 20 mL [(162.5mg/5mg/2.5mg/100mg)/5mL] PO q4hr

Child Dose

>12 years 2 tabs PO q4hr; not to exceed 12 tabs/24hr; not to exceed 1g/hr or 4g/day of Paracetamol 30 mL [(325mg/5mg/200mg)/15mL] PO q4hr 20 mL [(162.5mg/5mg/2.5mg/100mg)/5mL] PO q4hr

Renal Dose

Administration

Contra Indications

Hypersensitivity G-6-PD deficiency Severe hepatotoxicity

Precautions

Phenylephrine: Caution in elderly patients, hyperthyroidism, myocardial disease, bradycardia, partial heart block or severe arteriosclerosis Paracetamol: Hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many OTC products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose Paracetamol: Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash Guaifenesin: not for administration in persistent cough associated with chronic bronchitis, smoking, asthma, or accompanied with excessive secretions

Pregnancy-Lactation

Pregnancy category: C Lactation: excreted in breast milk, use caution

Interactions

Adverse Effects

Side effects of Paracetamol + Phenylephrine + Guaifenesin : Frequency Not Defined Hypertension Severe peripheral and visceral vasoconstriction Tachycardia Dizziness Drowsiness Excitability Headache Restlessness Tremor Dermatologic rash Nausea Vomiting Anemia blood dyscrasias (neutropenia, pancytopenia, leukopenia) Bilirubin and alkaline phosphatase may increase

Mechanism of Action

Paracetamol blocks pain impulse generation peripherally & may inhibit the generation of prostaglandin in the CNS; reduces fever by inhibiting the hypothalamic heat-regulating center Phenylephrine is a vasoconstrictor and decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue; shrinks swollen mucous membranes, reduces nasal congestion and tissue hyperemia Guaifenesin increases respiratory tract fluid secretions and helps to loosen phlegm and bronchial secretions.