Paracetamol + Pseudoephedrine

Indications

Paracetamol + Pseudoephedrine is used for: Relief of Cold & Flu Symptoms

Adult Dose

Relief of Cold & Flu Symptoms 2 caplets [(325mg/30mg)/caplet] PO q4-6hr; not to exceed 12 caplets/24hours 2 caplets [(500mg/30mg)/caplet] PO q6hr; not to exceed 8 caplets/24hours

Child Dose

Relief of Cold & Flu Symptoms 6-12 Years Old 1 caplet [(325mg/30mg)/caplet] PO q4-6hr; not to exceed 12 caplets/24hours >12 Years Old 2 caplets [(325mg/30mg)/caplet] PO q4-6hr; not to exceed 12 caplets/24hours 2 caplets [(500mg/30mg)/caplet] PO q6hr; not to exceed 8 caplets/24hours

Renal Dose

Administration

Contra Indications

Documented hypersensitivity to the drugs or within 14 days of MAO inhibitor therapy; known G-6-PD deficiency

Precautions

Caution in cardiovascular disease, diabetes mellitus, prostatic hypertrophy and increased intraocular pressure when taking pseudoephedrine Paracetamol hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many OTC products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose Paracetamol: Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Paracetamol + Pseudoephedrine : Common Adverse Effects Arrhythmia Palpitations Convulsion Dizziness Drowsiness Excitability Tremor Dermatologic rash Anemia blood dyscrasias (neutropenia, pancytopenia, leukopenia) Bilirubin and alkaline phosphatase may increase Weakness

Mechanism of Action

Paracetamol blocks pain impulse generation peripherally and may inhibit the generation of prostaglandin in the CNS. Reduces fever by inhibiting the hypothalamic heat-regulating center. Pseudoephedrine stimulates the alpha-adrenergic receptors causing bronchodilation and vasoconstriction.