Paracetamol + Pseudoephedrine + Guaifenesin
Indications
Paracetamol + Pseudoephedrine + Guaifenesin is used for:
Temporary Relief of Minor Aches & Pains, Headache, Nasal Congestion
Adult Dose
Temporary Relief of Minor Aches & Pains, Headache, & Nasal Congestion
2 tablets PO q4-6hr; not to exceed 8 capsules/day; not to exceed 1 g acetaminophen/4hr and 4 g Paracetamoln/day
Child Dose
Temporary Relief of Minor Aches & Pains, Headache, & Nasal Congestion
>12 years
2 tablets PO q4-6hr; not to exceed 8 capsules/day; not to exceed 1 g acetaminophen/4hr and 4 g Paracetamol/day
Renal Dose
Administration
Contra Indications
Hypersensitivity
Within 14 days of MAO inhibitor therapy
G-6-PD deficiency
Severe hepatic impairment
Precautions
Cardiovascular disease, diabetes mellitus, prostatic hypertrophy & increased intraocular pressure may occur with pseudoephedrine
Paracetamol hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many OTC products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose
Paracetamol : Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash
Guaifenesin is not for administration in persistent cough associated with chronic bronchitis, smoking, asthma, or accompanied with excessive secretions
Pregnancy-Lactation
Pregnancy category: C
Lactation: excreted in breast milk, use caution
Interactions
Adverse Effects
Side effects of Paracetamol + Pseudoephedrine + Guaifenesin :
Frequency Not Defined
Arrhythmia
Palpitations
Convulsion
Dizziness
Drowsiness
Excitability
Headache
Tremor
Nausea
Vomiting
Dermatologic rash
Anemia blood dyscrasias (neutropenia, pancytopenia, leukopenia)
Bilirubin & alkaline phosphatase may increase
Weakness
Mechanism of Action
Paracetamol blocks pain impulse generation peripherally and may inhibit the generation of prostaglandin in the CNS; reduces fever by inhibiting the hypothalamic heat-regulating center
Pseudoephedrine: stimulates the alpha-adrenergic receptors causing bronchodilation & vasoconstriction
Guaifenesin: increases respiratory tract fluid secretions and helps to loosen phlegm and bronchial secretions