Paromomycin
Indications
Paromomycin is used for:
Intestinal amoebiasis, Hepatic Coma (Adjunctive), Tapeworm
Adult Dose
Intestinal Amebiasis (E. Histolytica)
25-35 mg/kg/day PO divided q6hr for 5-10 days
Effective in acute and chronic but not extraintestinal
Hepatic Coma (Adjunctive)
4 g PO qDay in divided doses for 5-6 days
Diantomoeba Fragilis
20-30 mg/kg/day PO divided q8hr
Tapeworm (T. saginata/T. solium/D. latum/D. caninum)
11 mg/kg PO divided q15min for 4 doses
Dwarf Tapeworm
45 mg/kg/dose PO qDay for 5-7 days
Child Dose
E. Histolytica
25-35 mg/kg/day divided q8hr PO for 7 days OR
750 mg/m²/day divided q6hr PO for 5 days
Dientamoeba Fragilis
25-30 mg/kg/day PO divided q8hr for 7 days
Intestinal Amebiasis
25-35 mg/kg/day PO divided q8hr for 5-10 days
Tapeworm (Hymenolepis nana)
45 mg/kg PO qDay for 5-7 days
Tapeworm (T. saginata/T. solium/D. latum/D. caninum)
11 mg/kg PO divided q15min for 4 doses
Dwarf Tapeworm
45 mg/kg/dose PO qDay for 5-7 days
Renal Dose
Administration
Should be taken with food. Take during meals.
Contra Indications
Hypersensitivity to paromomycin and other aminoglycosides. Intestinal obstruction.
Precautions
Patient w/ ulcerative bowel lesions. Prolonged use may result in overgrowth of non-susceptible organisms. Renal impairment. Pregnancy and lactation.
Pregnancy-Lactation
Pregnancy Category: C
Lactation: does not enter breast milk
Interactions
Adverse Effects
Side effects of Paromomycin :
1-10%
Diarrhea
Abdominal cramps
Nausea
Vomiting
Heartburn
<1%
Headache
Vertigo
Exanthema
Rash
Pruritus
Steatorrhea
Secondary enterocolitis
Eosinophilia
Ototoxicity
Mechanism of Action
Aminoglycoside; interferes with bacterial protein synthesis by binding to 30S ribosomal subunits; has antibacterial against pathogenic organisms in the GI tract