Permethrin 5% Topical
Indications
Permethrin 5% Topical is used for:
Scabies, Pediculosis pubis
Adult Dose
Topical
Scabies
Adult: (30 gm tube) : A full tube.
Apply to skin surfaces from neck to toes. Wash off after 8-14 hr.
May reapply in 7 days
Pediculosis capitis, Pediculosis pubis
Apply to washed hair and leave on for 10 mins before rinsing with water.
May reapply in 7 days
Child Dose
Topical
Scabies
Children over 12 years(30 gm tube) : A full tube.
Children aged 6-12 years : Up to 1/2 of a tube.
Children aged 1-5 years : Up to 1/4 of a tube.
Children aged 2 months to 1 year: Up to 1/8 of a tube.
Apply to skin surfaces from neck to toes. Wash off after 8-14 hr.
May reapply in 7 days
Pediculosis capitis, Pediculosis pubis
Apply to washed hair and leave on for 10 mins before rinsing with water.
May reapply in 7 days
Renal Dose
Administration
Contra Indications
Hypersensitivity.
Precautions
Avoid contact with eyes and mucous membranes. Cross-sensitivity may occur with ragweed or chrysanthemums. History of asthma. Pregnancy and lactation.
Lactation: Not known if distributed in breast milk; may temporarily withhold the drug while the mother is nursing
Pregnancy-Lactation
Pregnancy Category: B
Lactation: Not known if distributed in breast milk; may temporarily withhold the drug while the mother is nursing
Interactions
Mild and transient burning, stinging, pruritus, erythema, tingling, numbness, rash; difficulty in breathing; phototoxic or photosensitisation reactions.
Adverse Effects
Side effects of Permethrin 5% Topical :
1-10%
Mild and transient burning and stinging (10%)
Pruritus (7%)
Mechanism of Action
Permethrin is a pyrethroid pediculocide and scabicide. It causes paralysis and death of the pest by inhibiting sodium ion influx through nerve cell membrane channels delaying repolarisation.