Pheniramine Maleate

Indications

Pheniramine Maleate is used for: Allergic conditions, Motion sickness, Allergic conjunctivitis, Allergic rhinitis, Hypersensitivity reactions, Hay fever, Uritcaria with pruritus, Neurodermatitis

Adult Dose

Oral Allergic conditions Adult: Syrup: 15-30 mg bid or tid. Tablet: Up to 45 mg tid. Max: 3 mg/kg/day. Elderly: Syrup: 15-30 mg bid or tid. Tablet: Up to 45 mg tid. Max: 3 mg/kg/day. Prophylaxis of motion sickness Adult: Syrup: 15-30 mg bid or tid. Tablet: Up to 45 mg tid. Max: 3 mg/kg/day. Take 1st dose at least 30 min before travelling. Injection The dosage should be adjusted individually. When immediate or rapid response is desired, IV or IM injection should be used. 1-2 ml twice a day by I/M or slow IV Multi-dose vial is not recommended for IV use.

Child Dose

Oral Allergic conditions Child: Tablet 5-10 yr: Half a 45-mg tablet up to tid; Tablet: Up to 45 mg tid. >10 yr: Syrup: 15-30 mg bid or tid. Max: 3 mg/kg/day. Prophylaxis of motion sickness Child: As maleate: 5-10 yr: Half a 45-mg tablet up to tid; >10 yr: Syrup: 15-30 mg bid or tid. Tablet: Up to 45 mg tid. Max: 3 mg/kg/day. Take 1st dose at least 30 min before travelling. Injection Hypersensitivity reactions, Hay fever, Uritcaria with pruritus, Neurodermatitis Injection solution is administered to infants and children aged 6 months and up to 11 years by the intramuscular route. The recommended dose may be repeated at 12 hourly intervals until the acute symptoms have subsided. Children aged 2 years about 11-14 Kg body weight 0.5-0.7 ml I/M. Children aged 3-5 years 20 Kg body weight 0.8-1.3 ml I/M Children aged 6-11 years Up to about 35 Kg body weight 1.0-1.5 ml I/M

Renal Dose

Administration

Should be taken with food. Take after meals.

Contra Indications

Symptomatic prostatic hypertrophy; neonates and premature infants.

Precautions

May impair ability to drive or operate machinery. Has potential for abuse. Narrow angle glaucoma, asthma or severe CV disease. Antiemetic effect may mask signs of other conditions. Pregnancy and lactation. Elderly.

Pregnancy-Lactation

Interactions

May mask ototoxicity produced by aminoglycoside antibiotics. Potentially Fatal: Potentiation of CNS depression by alcohol, sedatives, opioids, barbiturates, hypnotics, narcoleptics. May increase antimuscarinic effect of MAOIs, atropine and TCAs.

Adverse Effects

Side effects of Pheniramine Maleate : Sedation. Hypersensitivity reactions. Lassitude, dizziness, tinnitus, inability to concentrate, incoordination, irritability, insomnia and tremors. Nausea, vomiting, diarrhoea, colic, epigastric pain, anorexia, dryness of mouth and constipation. Urinary retention. Palpitations, headache. Blurred vision, increased intraocular pressure. Muscular weakness. Rarely, blood dyscrasias e.g. agranulocytosis, haemolytic anaemia.

Mechanism of Action

Pheniramine is an alkylamine derivative with histamine H1-receptor antagonist effects. It also has anticholinergic and moderate sedative effects.