Pheniramine Maleate + Naphazoline HCl Eye prep
Indications
Pheniramine Maleate + Naphazoline HCl Eye prep is used for:
Itchy, Red eyes
Adult Dose
Ophthalmic
Ocular allergy
Adult: Apply 1-2 drops in the affected eye up to 4 times daily.
Child Dose
Allergic Conjunctivitis
<6 years: Not established
6 years or older: Apply 1-2 drops in the affected eye up to 4 times daily.
Renal Dose
Administration
Contra Indications
Hypersensitivity, Angle closure glaucoma.
Precautions
Glaucoma, hypertension, CV abnormalities, DM, hyperthyroidism, infection, or injury. Pregnancy and lactation. Avoid in infants and young children <6 yr. Rebound congestion may occur with prolonged use or overuse. Patient to seek medical advice if there is ocular pain, vision changes, worsening of redness or irritation of the eye or symptoms lasts >72 hr. Remove contact lens before use.
Lactation: Unknown whether distributed in breast milk, weigh benefits against risks
Pregnancy-Lactation
Interactions
Increased pressor effects with maprotiline or TCA. Possibility of severe hypertensive reaction with MAOI.
Adverse Effects
Side effects of Pheniramine Maleate + Naphazoline HCl Eye prep :
Blurring of vision, mild stinging and/or irritation, mydriasis and increased or decreased intraocular pressure. Ocular erythema. When used in high doses in elderly, naphazoline may liberate pigment granules from the iris.
Mechanism of Action
Naphazoline, an imidazoline derivative is a sympathomimetic with alpha-adrenergic activity. It produces vasoconstriction. When applied topically to mucous membranes, it reduces swelling and congestion. It is often used in combination with pheniramine, an alkylamine derivative antihistamine, in ophthalmic preparations.