Phenylephrine Hydrochloride 5% + Tropicamide 0.8% Eye prep

Indications

Phenylephrine Hydrochloride 5% + Tropicamide 0.8% Eye prep is used for: Uveal tract inflammation, Retinal photography, Refractive errors, Funduscopy, Slit lamp examination, Dilatation of the pupil

Adult Dose

Therapeutic purpose: Uveitis: 1-2 drops bid-qid or as required. Diagnostic purpose/Pre-operative purpose: Instill 1-2 drops in the eye(s) 15-20 minutes before examination. If examination is not conducted within 20–30 minutes, an additional drop may be placed in the eye(s) to prolong the effect.

Child Dose

Renal Dose

Administration

Contra Indications

Patients with hypersensitivity to any of the components and narrow angles or narrow angle glaucoma. Low birth weight infants and some elderly adults with severe arteriosclerotic cardiovascular or cerebrovascular disease. During intraocular operative procedures when the corneal epithelial barrier has been disturbed.

Precautions

Caution should be taken when administered with, or upto 21days after administration of monoamine oxidase (MAO) inhibitors as exaggerated adrenergic effects may result. The possibility of psychotic reactions and behavioral disturbances should be considered in patients who are hypersensitive to anticholinergic drugs. Use with extreme caution in infants.

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Phenylephrine Hydrochloride 5% + Tropicamide 0.8% Eye prep : Elevated IOP (occasionally), stinging, blurred vision, tachycardia, photophobia, headache, parasympathetic stimulation and allergic reactions. Systemic effects include arrhythmias, hypertension and coronary artery spasm.

Mechanism of Action

Phenylephrine is a sympathomimetic with mainly direct effects on alpha-adrenergic receptors and weak beta-adrenergic activity. It causes vasoconstriction of the arterioles of the nasal mucosa and conjunctiva; activates the dilator muscle of the pupil to cause contraction; produces vasoconstriction of arterioles in the body and produces systemic arterial vasoconstriction. Tropicamide is a tertiary amine antimuscarinic which causes relaxation of the sphincter muscle of the iris resulting in pupillary dilatation. It also causes paralysis of the ciliary muscle leading to loss of accommodation.