Pneumococcal Polysaccharide Conjugated Vaccine

Indications

Pneumococcal Polysaccharide Conjugated Vaccine is used for: Active immunization for the prevention of pneumococcal disease, Meningitis, Sepsis, Bacteraemic pneumonia, Pleural empyema, Bacteraemia, Pneumococcal pneumonia

Adult Dose

Not for adult

Child Dose

Intramuscular Active immunisation against pneumococcal disease Infant 6 wk-6 mth: 3-dose Primary series 1st dose given at 2 mth or at 6 wk of age, with 1-mth interval between doses. A booster dose is recommended at least 6 months after the last priming dose. 2-dose Primary series 2 doses w/ the 1st dose given at 2 mth of age, w/ 2-mth interval between 1st & 2nd dose. Infants 7-11 mth: 2 doses at least 1 mth apart, with the 3rd dose given in the 2nd yr of life. Infant & childn 12 mth-5 yr previously unvaccinated 2 doses w/ at least 2 mth interval between doses. Pre-term infant born at least 27 wk of gestation 3 doses w/ the 1st dose given at 2 mth of age, w/ 1-mth interval between doses. Booster dose Administer at least 6 mth after the last primary dose.

Renal Dose

Administration

Contra Indications

Hypersensitivity to any component of the vaccine. Febrile illness, acute disease, anaphylactic reaction to a previous dose, severe primary immunodeficiency.

Precautions

Severe renal, hepatic, cardiac, vascular &/or pulmonary dysfunction. Patients on immunosuppressants may be unable to attain required antibody titres. Pregnancy & lactation. Efficacy may be reduced in multiple myeloma, Hodgkin's and non-Hogkin's lymphoma, especially during treatment and in chronic alcoholism. Vaccine should be given 2 wk before starting immunosuppressive treatment or at least 3 mth after treatment completion.

Pregnancy-Lactation

Pregnancy Category: C Lactation: N/A

Interactions

Adequate response may not be elicited w/ immunosuppressants.

Adverse Effects

Side effects of Pneumococcal Polysaccharide Conjugated Vaccine : Local inj site reactions, warmth, erythema & swelling; fever, headache, malaise.

Mechanism of Action

These products convey active immunity via stimulation of production of endogenously produced antibodies .