Podophyllin 25% in Tincture of Benzoin
Indications
Podophyllin 25% in Tincture of Benzoin is used for:
Genital warts, benign papillomas (eg granuloma inguinale & plantar warts).
Adult Dose
Topical
Removal of benign epithelial growths eg venereal & common warts; benign papillomas (eg granuloma inguinale & plantar warts).
Apply not more than 1-2 mL in each treatment.
it is recommended the first application of (podophyllin) be left in contact for only a short time (30-40 minutes) to determine patient's sensitivity. To avoid systemic absorption, time of contact should be minimum time necessary to produce the desired result (1 to 4 hours, depending on condition of lesion and of patient),
Child Dose
Renal Dose
Administration
Thoroughly cleanse affected area. Use supplied applicator to apply (podophyllin) sparingly to lesion. Avoid contact with healthy tissue. Allow to dry thoroughly. Only intact (no bleeding) lesions should be treated. As podophyllin is a powerful caustic and severe irritant, it is recommended the first application of (podophyllin) be left in contact for only a short time (30-40 minutes) to determine patient's sensitivity.
To avoid systemic absorption, time of contact should be minimum time necessary to produce the desired result (1 to 4 hours, depending on condition of lesion and of patient). Large areas or numerous warts should not be treated at once.
Contra Indications
Podophyllin is contraindicated in diabetics, patients using steroids or with poor blood circulation. (podophyllin) should not be used on bleeding warts, moles, birthmarks or unusual warts with hair growing from them. It is recommended that podophyllin not be used during pregnancy
Precautions
Do not use (podophyllin) if wart or surrounding tissue is inflamed or irritated. Do not use on bleeding warts, moles, birthmarks or unusual warts with hair growing from them.
Pregnancy-Lactation
Pregnancy Category: X; not recommended
Lactation: Unknown; avoid during breastfeeding
Interactions
Adverse Effects
Side effects of Podophyllin 25% in Tincture of Benzoin :
Systemic effects due to topical use: Urticaria, transient fever, paresthesia, polyneuritis, paralytic ileus, pyrexia, leukopenia, thrombocytopenia, coma & death. Local effects: Severe necrosis & scaring of anogenital area, paraphimosis requiring circumcision, pseudoepitheliomatous hyperplasia.
Mechanism of Action
The mechanism of action of podophyllo toxin is based on inhibiting the polymerization of tubulin and arresting the cell cycle in the metaphase.