Prednisolone Acetate + Sulfacetamide Sodium Eye prep
Indications
Prednisolone Acetate + Sulfacetamide Sodium Eye prep is used for:
Steroid-responsive inflammatory ocular conditions, Inflammatory conditions of the palpebral and bulbar conjunctiva, Cornea, Chronic anterior uveitis and corneal injury, Conjunctivitis;
Adult Dose
Inflammation/Infection
Eye Ointment: 1/2 inch TID/QID & at bed time.
As eye drop: 2-3 drops 1-2hr during day & at bed time.
Child Dose
Renal Dose
Administration
Contra Indications
Allergies to sulfa, glaucoma, Herpes, vaccinia, varicella, & other viral diseases of cornea or conjunctiva, mycobacterial infection of eye, fungal diseases of ocular structures, hypersensitivity to any ingredients.
After uncomplicated removal of corneal foreign body.
Precautions
Use for short term only because of steroid concerns. Watch for hypersensitivity to sulfas & steroid side effects (superinfection, glaucoma, etc). The possibility of fungal infections of the cornea should be considered after prolonged corticosteroid dosing. Use with caution in patients with severe dry eye.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Prednisolone Acetate + Sulfacetamide Sodium Eye prep :
This medication may temporarily sting or burn your eyes for a minute or two when applied. Eye discomfort, dry eyes, tearing, itching, or redness may occur.
Adverse reactions have occurred with corticosteroid/antibacterial combination drugs which can be attributed to the corticosteroid component, the antibacterial component, or the combination.
Use of this medication for prolonged or repeated periods may result in a new type of eye infection (e.g., viral, fungal).
A very serious allergic reaction to this drug is unlikely. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, signs of infection (e.g., fever, persistent sore throat), easy bleeding/bruising, yellowing of the eyes/skin, dark urine.
Mechanism of Action
Prednisolone decreases inflammation by inhibition of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability. It suppresses the immune system by reducing the activity and production of the lymphocytes and eosinophils.
Sulfacetamide has bacteriostatic effect on a wide range of gram-positive and gram-negative organisms. It interferes with nucleic acid synthesis thus blocking conversion of PABA to the coenzyme dihydrofolic acid.