Proparacaine Hydrochloride 0.5% eye prep
Indications
Proparacaine Hydrochloride 0.5% eye prep is used for:
Corneal anesthesia, Foreign Bodies & Suture Removal
Adult Dose
Deep anesthesia as in cataract extraction:
Instill 1 drop every 5 to 10 minutes for 5 to 7 doses.
Removal of sutures, Removal of foreign bodies:
Instill 1 or 2 drops 2 or 3 minutes just prior to procedures
Tonometry:
Instill 1 or 2 drops immediately before measurement.
Child Dose
Deep anesthesia as in cataract extraction:
Instill 1 drop every 5 to 10 minutes for 5 to 7 doses.
Removal of sutures, Removal of foreign bodies:
Instill 1 or 2 drops 2 or 3 minutes just prior to procedures
Tonometry:
Instill 1 or 2 drops immediately before measurement.
Renal Dose
Administration
Contra Indications
This preparation is contraindicated in patients with known hypersensitivity to any component of the solution. This product should never be prescribed for the patient's own use.
Precautions
Use with caution and sparingly in patients with known allergies, cardiac disease, or hyperthyroidism
Any topical anesthetic can damage corneal epithelium; prolonged use not recommended
Lactation: Not known if distributed in milk; use caution
Pregnancy-Lactation
Pregnancy Category: C
Lactation: Not known if distributed in milk; use caution
Interactions
Adverse Effects
Side effects of Proparacaine Hydrochloride 0.5% eye prep :
Pupillary dilatation or cycloplegic effects have rarely been observed with proparacaine hydrochloride. The drug appears to be safe for use in patients sensitive to other local anesthetics, but local or systemic sensitivity occasionally occurs. Instillation of proparacaine in the eye at recommended concentration and dosage usually produces little or no initial irritation, stinging, burning, conjunctival redness, lacrimation or increased winking. However, some local irritation and stinging may occur several hours after the instillation.
Rarely, a severe immediate-type, apparently hyperallergic corneal reaction may occur which includes acute, intense and diffuse epithelial keratitis; a gray, ground-glass appearance; sloughing of large areas of necrotic epithelium; corneal filaments and, sometimes, iritis with descemetitis.
Allergic contact dermatitis with drying and fissuring of the fingertips has been reported. Softening and erosion of the corneal epithelium and conjunctival congestion and hemorrhage have been reported.
Mechanism of Action
Reversibly blocks nerve conduction near the site of application. May limit sodium ion permeability through the lipid layer of the nerve cell membrane.