Pyrantel Pamoate
Indications
Pyrantel Pamoate is used for:
Enterobiasis, Ascariasis, Worm infections, Trichinosis
Adult Dose
Oral
Single or mixed infections due to susceptible worms
Adult: 10 mg/kg as a single dose.
Ascariasis
Adult: 5 mg/kg as a single dose. Max: 1 g/dose.
For mass treatment programmes: 2.5 mg/kg as a single dose given 3-4 times a yr.
Necatoriasis
Adult: 10 mg/kg daily for 3-4 days or 20 mg/kg daily for 2 days.
Enterobiasis
Adult: 10 mg/kg repeated once after 2-4 wk. Max dose: 1 g/dose.
Trichinosis
Adult: 10 mg/kg daily for 5 days.
Child Dose
<2 years: Safety and efficacy not established
Oral
Single or mixed infections due to susceptible worms
Child: 10 mg/kg as a single dose.
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity
Precautions
Liver dysfunction, anaemia or severe malnutrition. Treat members in close contact with the patient.
Pregnancy-Lactation
Pregnancy Category: C
Lactation: unknown
Interactions
Potentially Fatal: Mutually antagonistic with piperazine.
Adverse Effects
Side effects of Pyrantel Pamoate :
Anorexia, nausea, vomiting, abdominal cramps, drowsiness, insomnia, diarrhoea, tenesmus, SGOT elevations, headache, dizziness, rash.
Mechanism of Action
Pyrantel is effective against roundworms (Ascaris), threadworms (Enterobius), hookworms and Trichostrongylus. Not effective against whipworm. Acts by paralysing the worms which get detached and are excreted by intestinal peristalsis.