Pyridoxine Hydrochloride
Indications
Pyridoxine Hydrochloride is used for:
Peripheral neuropathy, Vitamin B6 deficiency
Adult Dose
Oral
Prophylaxis of vitamin B6 deficiency states
Adult: 2.5-10 mg/d.
Nausea in Pregnancy
75 mg PO qD
Child Dose
Renal Dose
Administration
Should be taken with food. Preferably taken w/ meals.
Contra Indications
Hypersensitivity. Patients receiving levodopa.
Precautions
Drug interaction with Levodopa.
Pregnancy-Lactation
Pregnancy Category: A/C-when exceeding RDA recommendations
Lactation: Safe
Interactions
Isoniazid, penicillamine and oral contraceptives may result in greater requirement in pyridoxine dose. Reduces the effects of levodopa, phenobarbitone, altretamine and phenytoin.
Adverse Effects
Side effects of Pyridoxine Hydrochloride :
Severe peripheral neuropathies (with long-term admin of large doses). Unstable gait, Paresthesias, Decrease sensation, Decreased folic acid
Mechanism of Action
Pyridoxine is a water-soluble vitamin which functions in the metabolism of carbohydrates, proteins and fats. It is essential in Hb formation and GABA synthesis within the CNS. It also aids in the release of glycogen stored in the liver and muscles.