Reteplase (Recombinant plasminogen sctivator)
Indications
Reteplase (Recombinant plasminogen sctivator) is used for:
For lysis of acute pulmonary emboli, intracoronary emboli and management of myocardial infarction
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Reteplase (Recombinant plasminogen sctivator) :
Mechanism of Action
Reteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action.