Reteplase (Recombinant plasminogen sctivator)

Indications

Reteplase (Recombinant plasminogen sctivator) is used for: For lysis of acute pulmonary emboli, intracoronary emboli and management of myocardial infarction

Adult Dose

Child Dose

Renal Dose

Administration

Contra Indications

Precautions

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Reteplase (Recombinant plasminogen sctivator) :

Mechanism of Action

Reteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action.