Rimantadine
Indications
Rimantadine is used for:
Influenza A virus
Adult Dose
Oral
Influenza A
Adult: 100 mg twice daily.
Prophylaxis of influenza A
Adult: 100 mg twice daily.
Child Dose
Oral
Prophylaxis of influenza A
Child: 1-9 yr: 5 mg/kg (max: 150 mg) once daily;
>10 yr and <40 kg: 5 mg/kg/day in 2 divided doses;
>10 yr and >40 kg : 100 mg twice daily.
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<10 mL/min 100 mg daily
Administration
Contra Indications
Hypersensitivity to drugs of the adamantane class, such as rimantadine and amantadine.
Precautions
Renal or hepatic impairment. Elderly. Monitor for GI and CNS adverse reactions. May increase risk of seizures in patients with a history of epilepsy, discontinue treatment if seizure occurs. History of eczema or psychosis. Pregnancy.
Pregnancy-Lactation
Pregnancy Category: C
Lactation: enters breast milk
Interactions
Adverse Effects
Side effects of Rimantadine :
1-10%
Dizziness (2%)
Nervousness (1-2%)
Fatigue (1%)
Headache (1%)
Insomnia (2%)
Difficulty in concentrating (<2%)
Anxiety (1%)
Anorexia (2%)
Weakness (1%)
Nausea (3%)
Vomiting (2%)
Xerostomia (2%)
Abdominal pain (1%)
Anorexia (2%)
< 1%
Dyspnea
Agitation
Ataxia
Tachycardia
Tremor
Convulsions
Heart block
Hyperkinesias
Bronchospasm
Gait abnormality
Mechanism of Action
Inhibits viral replication of three subtypes of influenza A (H1N1, H2N2, H3N2) early in the viral replicative cycle. Has no activity against influenza B virus.