Roxatidine

Indications

Roxatidine is used for: Peptic ulcer, Gastritis, Zollinger-Ellison syndrome, GERD, Upper gastrointestinal haemorrhage

Adult Dose

Oral Peptic ulcer Adult: 150 mg at bedtime or 75 mg bid daily for 4-6 wk. Maintenance: 75 mg at bedtime. Gastro-oesophageal reflux disease Adult: 75 mg bid or 150 mg at bedtime for 6-8 wk. Gastritis Adult: 75 mg once daily in the evening. Zollinger-Ellison syndrome Adult: 75 mg bid. Premedication before anaesthesia Adult: 75 mg in the evening on the day before surgery and repeated 2 hr before induction of anaesthesia. Alternatively, 150 mg once on the night before surgery. Intravenous Upper gastrointestinal haemorrhage Adult: 75 mg bid via slow inj or infusion.

Child Dose

Renal Dose

Renal impairment: CrCl (ml/min) Dosage Recommendation 20-50 75 mg at bedtime. <20 75 mg every 2 days.

Administration

Contra Indications

Lactation. Porphyria.

Precautions

Renal and hepatic impairment, pregnancy. May mask the symptoms of gastric malignancy.

Pregnancy-Lactation

Interactions

May affect serum levels of protease inhibitors.

Adverse Effects

Side effects of Roxatidine : Occasional headache, GI disturbances, gynaecomastia, alopecia, blood dyscrasias, pancreatitis, sleep disturbances, restlessness, rarely dizziness. Hypersensitivity reactions e.g. rash and itching reported occasionally. Changes in pulse rate and transient impairment of sexual drive. Possible increase in liver enzyme activity. May reduce leucocytes and/or thrombocytes.

Mechanism of Action

Roxatidine is a potent and selective inhibitor of basal and stimulated gastric acid secretion through competitive blockade of H2-receptors. Total pepsin secretion is reduced in a dose-dependent manner. There is an independent mucosal protection action.