Rupatadine

Indications

Rupatadine is used for: Allergic rhinitis, Chronic idiopathic urticaria

Adult Dose

Oral Allergic rhinitis; Chronic idiopathic urticaria Adult: 10 mg (1 tablet) once daily.

Child Dose

Oral Allergic rhinitis; Chronic idiopathic urticaria Tablet Child > 12 years: 10 mg (1 tablet) once daily. Children: Use of Rupatadine is not recommended in patients less than 12 years of age. Syrup: Children aged 2 to 11 years: Children weighing 10 kg to less than 25 kg: 1/2 teaspoonful (2.5 ml) syrup once a day with or without food. Children weighing 25 kg or more: 1 teaspoonful (5ml) of syrup once a day with or without food.

Renal Dose

Administration

Contra Indications

Hypersensitivity. Avoid alcohol.

Precautions

Renal or hepatic insufficiency. May impair ability to drive or operate machinery. Pregnancy, lactation. Elderly, children <12 yr.

Pregnancy-Lactation

Interactions

Increased CNS depressant effects when used with CNS depressants or alcohol.

Adverse Effects

Side effects of Rupatadine : Headache, somnolence, fatigue/asthenia.

Mechanism of Action

Rupatadine acts as a long-acting, non-sedative antagonist at histaminergic H1-receptors. Rupatadine also antagonises the platelet-activating factor (PAF). Both histamine and PAF cause bronchoconstriction and lead to an increase in the vascular permeability, acting as mediators in the inflammatory process.