Salicylic acid, Sulphur (precipitated)

Indications

Salicylic acid, Sulphur (precipitated) is used for: SALICYLIC ACID
Key additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts
SULFUR
Sulphur has been administered internally for all sorts of skin diseases, generally without any good result, but occasionally chronic eczema associated with much itching appears to be benefited by it, so that the sulphur lozenge is a suitable laxative for these cases. Sulphur has been also given for bronchitis, for chronic rheumatism, and rheumatic myalgia, but it is very doubtful whether in these diseases there is much relief from this treatment

Adult Dose

Child Dose

Renal Dose

Administration

Contra Indications

Precautions

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Salicylic acid, Sulphur (precipitated) :

Mechanism of Action

SALICYLIC ACID
Salicylic acid directly and irreversibly inhibits the activity of both types of cyclo-oxygenases (cox-1 and cox-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. Salicylate may competitively inhibit prostaglandin formation. Salicylate's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms. Salicylic acid is a key ingredient in many skin-care products for the treatment of acne, psoriasis, calluses, corns, keratosis pilaris, and warts. It works by causing the cells of the epidermis to slough off more readily, preventing pores from clogging up, and allowing room for new cell growth. Because of its effect on skin cells, salicylic acid is used in several shampoos used to treat dandruff. Salicylic acid is also used as an active ingredient in gels which remove verrucas (plantar warts). Salicylic acid inhibits the oxidation of uridine-5-diphosphoglucose (udpg) competitively with nicotinamide adenosine dinucleotide (nad) and noncompetitively with udpg. It also competitively inhibits the transferring of glucuronyl group of uridine-5-phosphoglucuronic acid (udpga) to the phenolic acceptor. The wound-healing retardation action of salicylates is probably due mainly to its inhibitory action on mucopolysaccharide synthesis
SULFUR
Sulphur itself has no action on the skin, but some of it is converted into hydrogen sulphide, and that is a mild vascular stimulant, causing slight dilatation of the vessels, and in some persons, eczema. It kills the sarcoptes scabiei, and is therefore a parasiticide