Serratiopeptidase

Indications

Serratiopeptidase is used for: Inflammation and oedema associated with traumatic injury and infection e.g., sinusitis, cystitis, bronchitis.

Adult Dose

By mouth, 5 to 10 mg (10000 to 20000 units) 3 times daily References: 1. Chappi D M, Suresh KV, Patil MR, Desai R, Tauro DP, Bharani K N S S, et al. Comparison of clinical efficacy of methylprednisolone and serratiopeptidase for reduction of postoperative sequelae after lower third molar surgery. J Clin Exp Dent. 2015 Apr 1;7(2):e197–202 2. Mathew JR. Use of oral enzyme preparations: Is there any evidence? Indian J Plast Surg. 2004 Jan 1;37(1):80

Child Dose

Child (<18 years): Not recommended

Renal Dose

Administration

Take 2 hours after a meal

Contra Indications

Hypersensitivity to serratiopeptidase or any of the excipients Blood coagulation disorder

Precautions

Liver and kidney disease; Pregnancy, breastfeeding

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Serratiopeptidase : Skin rash; Gastric discomfort, nausea, vomiting; Anorexia; Hepatitis, Jaundice; Stevens-Johnson’s syndrome, hypersensitivity reaction

Mechanism of Action