Sodium Hypochlorite 0.5% Topical
Indications
Sodium Hypochlorite 0.5% Topical is used for:
Water purification, Root canal operation, infection of the skin and tissue, irrigate or cleanse a wound before and after surgery or to treat cuts, abrasions, and skin ulcers.
Adult Dose
Pour sodium hypochlorite on or apply to the affected area as directed.
Pour, apply or spray affected area as an irrigation or cleanser. It is also used to wet certain types of wound dressings (e.g., wet to moist dressing).
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity to any ingredient in sodium hypochlorite or to chlorine compounds. Pregnancy, breast-feeding.
Precautions
This product is for external use only. Avoid contact with the eyes, ears, nose, and mouth. If you get sodium hypochlorite in your eyes, rinse immediately with cool water.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Sodium Hypochlorite 0.5% Topical :
Skin irritation. Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).
Mechanism of Action
The exact mechanism by which free chlorine destroys microorganisms has not been elucidated. Inactivation by chlorine can result from a number of factors: oxidation of sulfhydryl enzymes and amino acids; ring chlorination of amino acids; loss of intracellular contents; decreased uptake of nutrients; inhibition of protein synthesis; decreased oxygen uptake; oxidation of respiratory components; decreased adenosine triphosphate production; breaks in DNA; and depressed DNA synthesis. The actual microbicidal mechanism of chlorine might involve a combination of these factors or the effect of chlorine on critical sites.