Stanozolol
Indications
Stanozolol is used for:
Behcet's syndrome, Hereditary angioedema, Anaemia, Breast cancer in postmenopausal women, Catabolic disorders, Osteoporosis
Adult Dose
Oral
Vascular manifestations of Behcet's syndrome
Adult: 10 mg daily.
Hereditary angioedema
Adult: Initially, 2.5-10 mg daily, reduced according to response. Maintenance: 2 mg daily or on alternate days or 2.5 mg 3 times wkly.
Intramuscular
Osteopetrosis; Anaemia; Breast cancer in postmenopausal women; Catabolic disorders
Adult: 50 mg every 2-3 wk.
Child Dose
Oral
Hereditary angioedema
Child: <6 yr: 1 mg daily;
6-12 yr: Up to 2 mg daily.
Renal Dose
Administration
Contra Indications
Pregnancy and lactation; carcinoma of prostate or breast in men, hypercalcaemia, hypercalciuria, porphyria, severe hepatic impairment.
Precautions
Patients with cardiac, renal or hepatic disease, epilepsy or DM. Children, elderly. Monitor liver function, haematocrit and haemoglobin concentrations. Not recommended for treatment of hereditary angioedema in premenopausal women.
Pregnancy-Lactation
Interactions
Enhances activity of insulin, sulfonylureas, levothyroxine and anticoagulants e.g. warfarin. May cause resistance to the effects of neuromuscular blockers.
Adverse Effects
Side effects of Stanozolol :
Peliosis hepatis, premature epiphyseal closure, cholestatic jaundice, virilism, impotence, priapism, testicular atrophy, gynaecomastia, prostatic hyperplasia, decreased libido, hirsutism, menstrual irregularities; oedema, acne.
Potentially Fatal: Hepatic necrosis, hepatocellular carcinoma.
Mechanism of Action
Stanozolol is a structural analogue of testosterone which increases collagen production and decreases the anti-anabolic action of cortisone. It is also reported to reduce fibrin deposition. It corrects the formation of kinin or kinin-like factors which may be associated with oedema and swelling seen in hereditary angioedema.