Sulfanilamide vaginal prep
Indications
Sulfanilamide vaginal prep is used for:
Vulvovaginal candidiasis
Adult Dose
Vaginal
Vulvovaginal candidiasis
Adult: As vaginal cream: 1 applicator ful (about 6 g of 15% cream) once or bid for 30 days. As vaginal suppository: 1 suppository (1.05 g) bid for 7 days.
Child Dose
Renal Dose
Administration
Contra Indications
Sensitivity to sulfonamides; lactation.
Precautions
Third trimester of pregnancy
Severe blook reactions including aplastic anemia, agranulocytosis, and other blood dyscrasias reported
Severe reactions including toxic epidermal necrolysis, and Stevens Johnson syndrome reported
Fulminant hepatic necrosis reported with sulfonamides regardless of route
Discontinue if skin rash reaction occurs
Pregnancy-Lactation
Pregnancy Category: C
Lactation: Not recommended
Interactions
Adverse Effects
Side effects of Sulfanilamide vaginal prep :
Increased discomfort or burning sensation.
Mechanism of Action
Sulfanilamide is a short-acting sulfonamide with antibacterial activity is less than that of sulfamethoxazole. It interferes with the synthesis of nucleic acids in sensitive organisms by blocking the conversion of p-aminobenzoic acid (PABA) to the co-enzyme dihydrofolic acid.