Tafluprost
Indications
Tafluprost is used for:
Elevated Intraocular Pressure
Adult Dose
Elevated Intraocular Pressure
Indicated for reducing elevated IOP in patients with open-angle glaucoma or ocular hypertension
Instill 1 drop in affected eye(s) once daily in the evening
Child Dose
Renal Dose
Administration
Instill into conjunctival sac of affected eye(s)
Do not exceed once daily dosing regimen; more frequent administration of prostaglandin analogs may lessen the IOP lowering effect
Reduction of intraocular pressure starts approximately 2 - 4 hours after first administration with maximum effect reached after 12 hr
If other topical ophthalmics are prescribed, each should be administered 5 minutes apart
Contra Indications
Precautions
Causes changes to pigmented tissues; most frequently reported changes have been of the iris, eyelid, and eyelashes; pigmentation changes of the iris is likely permanent Increases length, color, thickness, and number of eyelashes
Caution with active intraocular inflammation (may exacerbate condition)
Macular edema reported; caution in aphakic patients, in pseudophakic patients with a torn posterior lens capsule, or with known risk factors for macular edema.
Lactation: Unknown whether distributed in breast milk.
Pregnancy-Lactation
Pregnancy Category: C; teratogenic when administered IV in rats and rabbits
Lactation: Unknown whether distributed in breast milk
Interactions
Adverse Effects
Side effects of Tafluprost :
>10%
Conjunctival hyperemia (4-20%)
1-10%
Ocular stinging (7%), Ocular pruritus/allergic conjunctivitis (5%), Cataract (3%), Growth of eyelashes (2%), Blurred vision (2%)
Mechanism of Action
Prostaglandin analog; exact mechanism by which it reduces IOP is unknown, but it is thought to increase uveoscleral outflow